The group aim is the study and assessment of the bioavailability and toxicity of existing and emerging contaminants and their mixtures. To this end, the group applies an array of lab toxicity tests (i.e. transgenic yeast, cell lines, zebrafish and Daphnia magna models), and field assays conducted with feral fish and invertebrates from both marine and freshwater environments. Effects are assessed across different biological levels using transcriptomic, lipidomics, metabolomics, morphogenetic and specific cell response, including effects on whole organism and population. During the last five years’ period (2013-2017) the group has produced 153 publications that have been cited 923 times (h index = 22). There is an active collaboration between group members in many of the mentioned research lines and they share 25 and 30 out of 153 publications (2013-2017 respectively).

Most important achievements of the group are:

1. Use of biomarkers and sentinel species to biomonitor contamination in marine and freshwater systems.
2. First evidence of endocrine disruption in fish (estrogenic effects in fish) and aquatic invertebrates (imposex in gastropods)
3. Application of -omic technologies to monitor effects and mode of action (MoA) on model species
4. Determination of the ‘obesogenic’ effect of contaminants in fish, fish cell lines and invertebrates
5. Development of animal-free bioassays for endocrine disruption and related toxic effects

  • Study the mechanisms of action of toxicants altering growth, reproduction, energetic metabolism, phototactic behavior in Daphnia magna using omic and functional assays.
  • Developing and use of cost-effective toxicity assays to identify toxic compounds in complex mixtures in the field
  • Elucidation of the molecular bases of the neurotoxic effects caused by some environmental pollutants and drugs using zebrafish as vertebrate model.
  • Gene expression in animal species of environmental interest
  • Cell death mechanisms
  • Identification of new biomarkers from transcriptomics and metabolomics analysis
  • Development of tissue and cell based bioassays for the detection endocrine disruption and related toxic effects
  • Lipidomic tools to monitor effects of contaminants and unravel toxicity pathways in model species

 

Research Facilities:

  • Four fully equipped labs to conduct biochemistry, molecular and analytical chemistry work.
  • Zebra fish housing facility
  • CT room to culture Daphnia magna and algae
  • Behavioural facility room
  • Microscopy facility room…
  • Histology facility room
  • Spectrofluorimeter microplate readers
  • Respirometry
  • Spectrometry
  • Genomics service equipped with real time PCR instruments (LC480, Roche), PCR termocycler (Biorad), Nanodrop Spectrophotometer, Bioanalyzer (Agilent technologies) and Gel Logic 200 Imaging System (Kodak)
  • Cell culture facility

 

Knowing the enemy

Knowing the enemy: a mechanistic approach to fight against OPIDN.

Start Date: 01/10/18

NeuroAquaTox

Development of medium- and high-throughput methodologies for chemical risk assessment in aquatic ecosystems: neurobehavioural effects and pathophysiological mechanisms in zebrafish and Daphnia magna. NeuroAquaTox.

Start Date: 01/01/18

dCod 1.0:decoding systems toxicology of cod (Gadus morthua) environmental genomics for ecosystem quality monitoring and risk assessment

Technology Transfer Contract

dCod 1.0:decoding systems toxicology of cod (Gadus morthua) environmental genomics for ecosystem quality monitoring and risk assessment. Project No.: DLSI_2016.

Start Date: 30/09/16

Interaction between synthetic organic pollutants and the microbial pump in coastal seawaters.

Interaction between synthetic organic pollutants and the microbial pump in coastal seawaters. Ministry of Economy and Competitiveness, Spain, CTM2015-65691-R.

Start Date: 01/01/16

Innovec’EAU

European Project

Residuos de fármacos en los efluentes de aguas residuales de centros para personas mayores (Establecimientos y residencias de ancianos): riesgos, nuevas herramientas de control y sistemas efectivos de tratamiento. Innovec’EAU

Start Date: 01/01/16

EMRISKS

Mechanistically-based environmental risk assessment: towards an omics-driven solution for an effective management of chemical risks. Ministry of Economy and Competitiveness, Spain, CTM2014-51985-R. (EMRISKS)

Start Date: 01/01/15

EpiSTOX

European Project

EPIgenetic Signatures as biomarkers of ecoTOXicological effects. European Comission. Europaid. H2020-MSCA-IF-2017.

Start Date: 01/01/15

Impacto ambiental de la cianamida cálcica en el mejillón

Technology Transfer Contract

Impacto ambiental de la cianamida cálcica en el mejillón. Tipo de contrato: I +D; Empresa/Administración financiadora: IRTA

Start Date: 01/01/15

Assessment of the toxicity of sediments from the Mediterranean basin: AN –OMIC APPROACH

Assessment of the toxicity of sediments from the Mediterranean basin: AN –OMIC APPROACH

Start Date: 01/05/14

Impacto ambiental de las saponinas usadas en el control del caracol manzana en el mejillón

Impacto ambiental de las saponinas usadas en el control del caracol manzana en el mejillón. Tipo de contrato: I +D; Empresa/Administración financiadora: IRTA, San Carles de la Ràpita

Start Date: 01/01/14

Chemageb

CHEMometric and High-Throughput Omics Analytical Methods for Assessment of Global Change Effects – (Chemageb)

Start Date: 01/04/13

CHEMAGEBE

European Project

CHEMometric and High-Throughput Omics AnalyticalMethods for Assessment of Global Change Effects on Environmental and Biological Systems (CHEMAGEBE- ERC-AdG2012

Start Date: 01/01/13

PERSEUS

Policy-oriented Marine Environmental Research in the Southern European Seas (PERSEUS)

Start Date: 01/01/12

HOLOTOX

Integrative approach to characterize new mechanisms of toxicity of pollutants in the aquatic environment. (HOLOTOX)

Start Date: 01/01/12

TEAPARTICLE

Health risks and toxicity mechanisms associated to Ambient air PM: correlation to particle size and chemical composition (TEAPARTICLE)

Start Date: 01/01/12

Caracterización de nuevos mecanismos de toxicidad de sustancias contaminantes en el medio acuático CTM2011-30471-C02-01

Caracterización de nuevos mecanismos de toxicidad de sustancias contaminantes en el medio acuático CTM2011-30471-C02-01

Start Date: 01/01/12

MIGRAPLAST

Migración de plastificantes y aditivos a bebidas refrescantes y aguas envasadas (MIGRAPLAST)

Start Date: 02/05/11

Impacto ambiental de las saponinas usadas en el control del caracol manzana

Technology Transfer Contract

Impacto ambiental de las saponinas usadas en el control del caracol manzana.; Tipo de contrato: I +D

Start Date: 01/01/11

Analysis of dioxin-like activity in water samples using the zebrafish scale assay

Technology Transfer Contract

Analysis of dioxin-like activity in water samples using the zebrafish scale assay. CETaqua, Centro Tecnológico del Agua.

Start Date: 01/01/10

Ensayos de toxicidad con nanomateriales 2

Technology Transfer Contract

Ensayos de toxicidad con nanomateriales 2

Start Date: 01/01/10

Analysis of specific toxicants in zebrafish scales

Technology Transfer Contract

Analysis of specific toxicants in zebrafish scales. CETaqua, Centro Tecnológico del Agua.

Start Date: 01/06/09

CEBRAPOP

Estudio de la estructura genética y diferenciación ecológica de las poblaciones españolas de mejillón cebra (Dreissena polymorpha) frente a factores ambientales de origen natural y antropogénico. Bases científicas para su control ambiental sostenible (CEBRAPOP)

Start Date: 01/01/08

Áreas Marinas Protegidas de Chile y España (MAPUCHE)

Áreas Marinas Protegidas de Chile y España (MAPUCHE): Una aproximación interdisciplinar al manejo y la conservación marina: experiencias divergentes como base de estrategias globales.

Start Date: 01/01/07

CEBRAGEST

Estudio de los mecanismos específicos de respuesta del mejillón cebra (Dreissena polymorpha) y de los bivalvos unionoideos (náyades) frente a impactos ambientales de origen natural y antropogénico. Bases científicas para su control ambiental sostenible (CEBRAGEST).

Start Date: 01/01/07

MOBITROF

Development of ecological test to measure stress in Ebro river organisms between Ribarroja Dam and the river Delta, and analysis of chemical risk due to impact of toxic sediments present in the Flix Dam

Start Date: 01/01/06

AQUATERRA

European Project

Integrated modelling of the river-sediment-soil-groundwater system. Global Change and Ecosystems Integrated Project (AQUATERRA-GOCE 505428).

Start Date: 01/01/04


Close Menu