Type

International Project

Start Date

03/06/2021

End Date

02/06/2024

Staff

Demetrio Raldúa Pérez

Project Leader

Melissa Faria

Researcher

Project Description

Human brain is a great target for chemical terrorism, so NATO nations should be prepared to respond effectively to terrorist threats involving neurotoxic industrial chemicals (neuroTICs). The main objective of this project is to assess the therapeutic potential of AD4 and thioredoxin-mimetic peptides, blood-brain barrier permeable drugs targeting oxidative stress, apoptosis and inflammation, on acute neurotoxic syndromes induced by three common TICs (organophosphorus compounds, acrylamide, organic mercury). Moreover, specific combinations of drugs derived from the analysis of potential therapeutic targets for each toxidrome will be also tested.

This project is supported by: The NATO Science for Peace and Security programme

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