Mahboubeh Hosseinzadeh Soureshjani
437746
mahboub.hosseinzadeh@idaea.csic.es
ORCID:
0000-0002-0033-2238
Research group: Environmental Toxicology
Mahboubeh Hosseinzadeh is a postdoctoral researcher at the Spanish National Research Council (CSIC). She is a BSc (University of Chamran-Ahvaz- Iran), MSc (the University of Gorgan–Iran), and Ph.D. (University of Tehran –Iran) graduate in Aquaculture. She started her research career as a postdoctoral researcher at the CSIC in 2019 in Dra. Cinta Porte’s laboratory in the Environmental Toxicology Department. She studied the impact of environmental contamination on aquatic organisms and humans by analyzing gene expression, lipidomics, enzymatic activity, and other molecular biology approaches. More specifically, she is currently focusing on plastic (additives, micro-, and nano-plastics) toxicity using human and fish cell lines.
BIOPLAS
New Approach Methodologies for evaluating the toxicity of biodegradable plastics and plastic additives
The occurrence of plastic and its associated chemicals in the aquatic environment is an issue of great social and economic concern.
Investigating the toxic effects of plastics and associated chemicals is a challenging task. In recent years, global research efforts are being
directed towards the development and application of New Approach Methodologies (NAMs) based on in vitro systems that do not require
the use of living organism and provide information on chemical hazard by elucidating the mechanisms of toxicity. Within this context, there
is growing interest in the development of models that predict realistic exposure scenarios using repeated or chronic exposures at lower
doses to provide more environmentally relevant results as well as reducing animal testing. Traditional two-dimensional (2D) cells culture or
monolayer cell cultures are a very useful approach, but have some limitations when predicting in-vivo effects. This has driven the
development of more realistic and predictive three-dimensional (3D) cell culture models to improve the prognostic capability of in vitro
testing systems
This project aims to improve the predictability and to validate selected NAMs (fish cell monolayers, spheroids, mussel explants) for toxicity
assessment of bio-based and biodegradable plastics, as well as plastic additives. The project explores the analysis of the lipidome and
proteome together with traditional toxicological data (cell viability, gene expression, enzymatic activities), to characterize the complexity of
the biological response and the alterations produced by a selected number of plastic extracts. The application of integrative and projection
models such as the adverse outcome pathway (AOP) will facilitate the linkage between molecular responses and an adverse outcome,
and will help to alert on the deterioration of aquatic systems.
This project, by developing new relevant cell models and high-throughput systems will provide integrative and reliable indicators of
environmental and health impact, from which both plastic producers and policy makers can benefit for a better management and protection
of natural resources and fulfil the social demand for a safer environment.
Funding: Ministerio de Ciencia e Innovación. PID2021-122592NB-I00
- IDAEA Personnel:
- Cinta Porte (PI)
- Mahboubeh Hosseinzadeh (postDoc)
- Tiantian Wang (PhD student)
- Gemma López (PhD student)
- Miquel Perrelló (PTA)
- Non-IDAEA Personnel:
- Montserrat Solé (ICM-CSIC, co-IP)
- Amparo Torreblanca (Universidad de Valencia)
Start Date: 01/09/2022 – End Date: 31/12/2025
Project Leader: Cinta Porte Visa
Researchers: Mahboubeh Hosseinzadeh Soureshjani
Support: Miquel Perelló Amorós , Tiantian Wang , Gemma López Llaó
Funding: National Project
Exploring the environmental quality and toxicity profiles of soils from major e-waste sites in West Africa
West Africa has been the recipient of used electrical and electronic equipment imported onto the African continent with Nigeria, Republic of Benin and Ghana as the main import hub. Only 25% of the imported equipment is reportedly functional while 75% are either unserviceable or waste and hence, ends up in informal e-waste sites. The informal recycling of e-waste as practiced in West Africa has the potential to release a large quantity of contaminants into the recycling sites and the surrounding environment. Environmental matrices such as soil in the vicinity of the e-waste sites could be contaminated following informal e-waste recycling practices. Many children and adolescents work in these e-waste sites, risking negative impacts on their health. The number of harmful substances that humans could be directly or indirectly exposed to by e-waste is vast. The concentrations of these materials are variable but often are notably high, especially within the actual e-waste sites. Endocrine disruption, neurotoxicity and genotoxicity are among the health threats that can be expected from the diverse materials that are handled and that contaminate soil in such areas. Therefore in this present study, we will explore the environmental quality and toxicity profile of soil from major e-waste sites in West Africa using several endpoints which represent well established methods of routine testing in substance safety assessment. Moreover, we will analyse some families of persistent organic pollutants such as halogenated flame retardants and plasticizers, whose high presence has already been detected in e-waste. The study will contribute to sustaining research into understanding how exposure to mixture of e-waste chemicals trigger and contribute to diseases. The study is timely and novel considering the need to obtain accurate scientific data on the effects of exposure to hazardous chemicals in single and joint form. The outcome of this study will be used to generate an initial environmental health risk assessment report comparing the observed toxicity of soil from major e-waste sites in West Africa in order to inform and focus monitoring plans and risk management strategies.
Programa CSIC de Cooperación Científico para el Desarrollo I-COOP 2022, ref.: COOPB22064
- Non-IDAEA personnel:
- Eze, Chukwuebuka, Federal University Oye-Ekiti (Nigeria)