Elisabet Pérez Albaladejo
Funded by Severo Ochoa project
Research group: Environmental Toxicology
After my degree in Animal Biology at the Universitat Autònoma de Barcelona (UAB), and a master's degree in Biodiversity at the Universitat de Barcelona (UB), I began my research career in the Environmental Chemistry Department at Institute of Environmental Assessment and Water Research (CSIC), and recently I have obtained my doctorate degree in Biodiversity (Ecotoxicology) by the UB (18/08/2017). My thesis, entitled " Uso de líneas celulares como modelos in vitro para la evaluación de toxicidad y mecanismos de acción de contaminantes ambientales", aimed to investigate the usefulness of different bioassays based on the use of fish and human cell lines and subcellular fractions for characterizing the environmental risk posed by pollutants for aquatic ecosystems and human health. The in vitro techniques we use allow studying the mechanisms of toxic action of various isolated xenobiotics (eg plasticizers, pesticides, perfluorinated compounds) as well as mixtures of pollutants in complex environmental matrices (eg marine sediments), including changes in lipid composition, effects of endocrine disruption, oxidative stress and activation of exposure biomarkers (eg AhR and PXR receptors). During my PhD, I had the opportunity to spend a three-month stay at the University of Bergen, where I gained new knowledge about recent techniques (eg transfection of cells with PXR zebrafish) focused on detecting the activation of cellular receptors involved in the detoxification and associated with lipid metabolism. These in vitro techniques are more economical and have proven to be a valid alternative to in vivo tests in environmental toxicology studies, contributing to the reduction of the use of experimental animals and toxic waste, while minimizing the risk of exposure of the researcher. . Thus, the objective of my future research continues in the same line, contributing to the better understanding and evaluation of the toxic effects of environmental pollution and its consequences on aquatic ecosystems and human health.