PhD Thesis Defense by Miguel Velázquez Gómez (IDAEA-CSIC) at the Sala Enric Casasses (Faculty of Chemistry), University of Barcelona
16th October 2019
Title: Organic pollutants in indoor dust: Method development, site-specific monitoring and human exposure
Speaker: Miguel Velázquez Gómez (IDAEA-CSIC)
Supervisors: Sílvia Lacorte, Researcher and Deputy director at IDAEA-CSIC.
PhD Thesis Committee: Teresa Moreno Pérez (IDAEA-SCIC), Joyce Cristale (Universidade Estaduale de Campinas, Brasil) and Ana Ballesteros Gómez (Universidad de Córdoba).
Date: Monday, 21st October 2019
Time: 10.30 a.m.
Venue: Sala Enric Casasses (Faculty of Chemistry), University of Barcelona.
Nowadays people spend more than a 90% of their time indoors. Dust has emerged as an important matrix to study human exposure to organic contamination. Its concerns for human health include from sensitization effects such as allergies to toxic effects derived from organic pollutants adsorbed to dust particles, such as neurotoxicity, endocrine disruption and carcinogenic responses.
The present PhD thesis aims to evaluate the presence of multi organic contaminants in dust to assess human exposure and risk by using empirical data and theoretical calculations.
A multi-residue extraction method based on solid-liquid ultrasound assisted extraction (UAE) and a gas chromatography coupled to tandem mass spectrometry was optimized to determine polycyclic aromatic hydrocarbons (PAHs), organophosphorus flame retardants (OPFRs), polychlorinated biphenils (PCBs), organochlorinated pesticides (OCs), phthalates, alkylphenols (APs), bisphenol A (BPA) and nicotine, all of them selected on a basis of their widespread use worldwide and toxic effects. The occurrence and risk of dust pollutants was evaluated in Barcelona (houses, cars, schools, public libraries and museums) and in the Ecuadorian Amazonia, an area affected by oil extraction. Further, exposure of contaminants through dust inhalation was evaluated by measuring target contaminants in nasal lavages. As a whole, the present PhD thesis outlines a connection among environmental analytical chemistry and other disciplines such as exposure science or environmental epidemiology. It attempts to serve as a tool to other knowledge areas and social groups to improve the understanding of the accumulation of organic pollutants in indoor dust and the related human exposure and potential disease outcomes.