Title: Integrating novel spatial and multi-omics to enhance toxicological assessment of endocrine disruptors
The predoctoral researcher Albert Menéndez Pedriza, from the Chemometrics for Environmental Omics group, will defend his thesis on 13th April at 11:00h in Aula Magna Enric Casassas (Facultat de Química i Física, Universitat de Barcelona)
Directors: Joaquim Jaumot and Laia Navarro.
Thesis Committee: Cinta Porte Visa, Rikke Poulsen and Ludovic Duponchel
Abstract:
Chemical pollution is widely recognized as a major global threat to environmental health, with endocrine-disrupting chemicals posing particular concern due to their complex biological effects. Traditional toxicity assessments often fail to capture their multi-level impact, limiting understanding of disrupted pathways. This thesis explores the potential of advanced omics technologies to address these gaps. By developing optimized spatial omics workflows and integrating multi-omics data through innovative analytical strategies, this work enhances the detection of sublethal molecular changes in model organisms. Overall, the results achieved demonstrate that integrating experimental and computational advances in omics can significantly enhance mechanistic insights into pollutant toxicity in environmental systems.
